Cysteamine as a New Pigment Correcting Agent

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Cysteamine hydrochloride (β-Mercaptoethylamine hydrochloride)

Novel Discovery in Skin Hyperpigmentation Correction


Cysteamine is the simplest aminothiol biosynthesised in the human cells. It is the product of degradation of the essential amino-acid L-cysteine and is synthesized by human body cells during the co-enzyme A metabolism cycle.  Cysteamine promotes the transport of L-cysteine into cells, that can be further used to synthesize glutathione, which is one of the most potent intracellular antioxidants.

Cysteamine has FDA approval for human use. It has a long history of oral use in human, for the treatment of cystinosis, and has potential for the treatment of radiation sickness, neurodegenerative diseases and cancer prevention.

Cysteamine has been previously shown by independent researchers to have significant depigmenting activity in in-vitro and animal studies. Cysteamine was never managed to be formulated into a topical product due to its fast oxidation leading to a very bad odor. Our new technology has enabled us to stabilize cysteamine and significantly reduce its odor in cream conditions for the first time.

Cysteamine Cream, Higher Efficacy Compared To Hydroquinone

Cysteamine cream has been recently introduced as a treatment for skin hyperpigmentary concerns. Well controlled-Clinical studies have consistently confirmed its efficacy in melasma. Pigment cell researchers have concluded in the higher efficacy of cysteamine compared to hydroquinone.

Cysteamine Cream, Superior Benefit/Risk Ratio Compared To Hydroquinone And Other Alternatives

Known skin depigmenting molecules such as hydroquinone and kojic acid have been recently shown to exhibit mutagenic and carcinogenic effects and have been restricted by the FDA and European authorities. Recently, Cysteamine cream has been introduced as a solution for skin hyperpigmentary concerns. Cysteamine is shown not to be mutagenic or carcinogenic and interestingly shows an anti-mutagenic, anti-cancer and anti-melanoma effect demonstrated in in vitro and in vivo models. Taken together cysteamine has a superior benefit/risk ratio compared to other alternatives and is considered as the new standard for hyperpigmentation concerns.



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Cysteamne Intensive Depigmenting Treatment